陈文生

陈文生副教授：医学博士，耶鲁大学博士后，研究所副所长。从医20余年，具有丰富的临床经验。从事肝胆汁淤积、肝硬化腹水和原发性肝癌发病机制及治疗研究。 擅长慢性肝病、慢性胃肠炎、消化性溃疡、消化系肿瘤的诊治。

先后主持四项国家自然科学基金研究课题。在JBC、AJP和Hepatology发表论文10篇。任中华消化病学会肝胆疾病协作组成员。主要发表论文如下：

1.Nuclear receptors RXRα:RARα are repressors for human MRP3 expression。Am J Physiol Gastrointest Liver Physiol.2007; 292: G1221-G1227

2. Tumor necrosis factor a–dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem 2003; 278(38): 36688-98

3. A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology. World J Gastroenterol 2006; 12(16):2536-2548.

4. Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells. J Gastroenterol Hepatol. 2003 Mar;18(3):296-301

5. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 2004; 40: 585-591.

6. Release of transcriptional repression from RXRalpha and RARalpha results in up-regulation of MRP3 in obstructive cholestasis. Hepatology 2004;40(4), suppl. 170A

7. Plasma membrane localization of human organic anion-transporting polypeptide C (hOATP-C). Hepatology 38(4), suppl. 1 487A, 2004.

8. The cholesterol-7a hydroxylase promoter factor (CPF) up-regulates the human multidrug resistance-associated protein 3 (MRP3) and is induced by bile salts in HepG2 cells. Hepatology 2003; 38(4) Suppl. 1: 195A

9. MRP3/Mrp3 (ABCC3/Abcc3) is up-regulated by TNF via cholesterol 7 hydroxylase promoter factor (CPF) and is hepatoprotective in obstructive cholestasis. Hepatology 2003; 38(4) Suppl. 1: 168A

10. Nuclear hormone regulation of the human multidrug resistance protein (MRP3) gene in human hepatoma cell lines。Hepatology 2002; 36(4) Suppl. 2: 343A.