董旻岳

1985年毕业于浙江医科大学医学系，2000-2001年在美国伊利诺依大学芝加哥分校(UIC)医学院从事生殖生理学研究。研究领域为生殖医学、围产医学和生殖遗传学，主要研究方向为妊娠免疫耐受机制、生殖和妊娠相关疾病的免疫学病因与发病机制，以及遗传性出生缺陷的防控研究。主持、承担国家自然科学基金、973项目子课题等课题多项。发表学术论文百余篇，主要论文均发表在SCI刊物，获国家科技进步奖二等奖、浙江省科技进步一等奖等科技成果奖励6项。

研究方向：

生殖医学、围产医学

主要在研课题：

1. Follistatin-like 3对滋养细胞与胚胎的影响以及在妊娠并发症中的作用。2013年国家自然科学基金(课题负责人)

2. 子宫内膜细胞脂肪酸结合蛋白4在胚胎着床中的作用与机制研究。2011年国家自然科学基金(课题负责人)

3. 辅助生殖诱发胚胎源性疾病的风险评估和机制研究。2011年国家重大科学研究计划(973)项目(学术骨干)

4. Toll样受体7、8介导的炎性反应通路在滋养细胞阻止乙型肝炎病毒宫内传播中的作用。2010年浙江省自然科学基金(课题负责人)

近五年成果获奖：

1. 提高出生人口质量的生殖技术创建、体系优化与临床推广应用：2010年国家科技进步二等奖;

2. 阻断出生缺陷、促进子代健康关键技术体系的创建与推广应用：2010年浙江省科技进步一等奖;

近五年发表的代表性论文(*为通讯作者)：

1. He J, Zhang AP, Fang M, Fang R, Ge JM, Jiang Y, Zhang H, Han C, Ye XQ, Yu DQ, Huang HF, Liu Y*, Dong MY*. Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies. BMC Genomics, 2013, 14:472.

2. Zhou QY, Li J, Wang HZ, Han C, Tian T, Zhu QY, Huang HF, Dong MY*. Serum preadipocyte factor-1 is increased in fetuses of pregnancy complicated with severe preeclampsia. Clinica Chimica Acta, 2013, 424:212-215.

3. Guo J, Tian T, Lu DH, Xia GY, Wang HZ, Dong MY*. Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia. J Obstet Gynecol Res, 2012 Jul, 38( 7):988-996.

4. Hu DX, Tian T, Guo J, Wang HZ, Chen DQ, Dong MY*. Decreased maternal and placental concentrations of follistatin-like 3 in gestational diabetes. Clinica Chimica Acta, 2012, 413: 533-536.

5. Yin LJ, Zhang Y, Lv, PP, He WH, Wu YT, Liu AX, Ding GL, Dong MY, Qu F, Xu CM, Zhu XM, Huang HF. Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Med. 2012;10:26.

6. Liu FJ, Guo J, Tian T, Wang HZ, Dong FY, Huang HF, Dong MY*. Placental trophoblasts shifted Th1 ⁄ Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface. APMIS, 2011, 119: 597–604.

7. Wang N, Wang, LY, Le F, Zhan QT, Zheng YM, Ding GL, Chen XJ, Sheng JZ, Dong MY, Huang HF, Jin F. Altered expression of Armet and Mrlp51 in the oocyte, preimplantation embryo, and brain of mice following oocyte in vitro maturation but postnatal brain development and cognitive function are normal. Reproduction, 2011,142( 3):401-408.

8. Chen D, Xia G, Xu P, Dong MY*. Peripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes. Acta Obstet Gynecol Scand. 2010, 89(12): 1595- 1599.

9. Zhang K, He J, Dong MY*. Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet. 2010;111(2):187-8.

10. Wang TT, Wu YT, Dong MY, Sheng JZ Leung PC, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. FERTILITY AND STERILITY. 2010; 94(6): 2490-2492.

11. Liang ZX, Dong MY, Cheng Q, Chen DQ. Gestational diabetes mellitus screening based on the gene chip technique. Diabetes Res Clin Pract, 2010 Aug, 89(2):167-73.

12. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. HUMAN REPRODUCTION, JUN 2010, 25(6): 1441-1450

13. Ding GL, Chen XJ, Luo Q, Dong MY, Wang N, Huang HF. Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid. FERTILITY AND STERILITY, MAY 2010, 93(8): 2538-2544

14. Wei J, Wang HM, Yang XF, Dong MY, Wang ZP. Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy. Arch Gynecol Obstet, 2010 May, 281( 5): 801-10

15. Lou H, Ding W, Dong MY, Zhu Y, Zhou C, Wang Z, Yang X, Yao Q, Li D, Miao M. The Presence of Hepatitis B Surface Antigen in the Ova of Pregnant Women and Its Relationship with Intra-uterine Infection by Hepatitis B Virus. J Int Med Res, 2010, 38(1): 214-9

16. Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PCK, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol, 2009, 7:

17. Shangguan XJ, Liu FJ, Wang HZ, He J, Dong MY*. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clinica Chimica Acta, 2009, 407: 58-61

18. Chen DQ, Wang HZ, Huang HF, Dong MY*. Vascular Endothelial Growth Factor Attenuates Nω-Nitro-L-Arginine Methyl Ester-Induced Preeclampsia-Like Manifestations in Rats. Clinical and Experimental Hypertension. 2008 Oct, 30(7): 606- 615.

19. Chen X, Qian X, Chen H, Dong M*. Serum levels of nitric oxide metabolites during labour with or without combined spinal-epidural analgesia. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2008 Sep, 25 (9): 708-713

20. Feng C, Wang LQ, Dong M, Huang HF. Need for standardization and confirmation of STS deletions on the Y chromosome – Reply. FERTILITY AND STERILITY. 2008 Aug, 90 (2): 464-464

21. Feng C, Wang LQ, Dong M*, Huang HF. Assisted reproductive technology may increase clinical mutation detection in male offspring. FERTILITY AND STERILITY, 2008 Jul, 90(1): 92-96.

22. Huang H, Dong M*. The effect of trohphoblasts on T lymphocytes and the role of indoamine 2,3-dioxigenase. Human Reproduction. 2007 Jul, 22 (Supl 1): 112-112 Meeting abstract O028.

23. Minyue Dong*, Guolian Ding, Jun Zhou, Hanzhi Wang,Yi Zhao, Hefeng Huang. The effect of trohphoblasts on T lymphocytes: Possible regulatory effector molecules--A proteomic analysis. Cellular Physiology and Biochemistry, 2008, 21:463-472.

24. Wensheng HU, Zhengping WANG，Hanzhi WANG, Hefeng HUANG and Minyue DONG*. Serum Visfatin Levels in Late Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008 April, 87(4): 413-418.

25. Dongxiao Hu, Zhengping Wang, Wuwen Zhang, Hanzhi Wang, and Minyue Dong*. Alteration of Peripheral CD4+CD25+ Regulatory T Lymphocytes in Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008, 87(2): 190-194.

26. Qingxia Meng, Huijuan Gao, Chengming Xu, Minyue Dong, Xia Sheng, Jiangzhong Sheng, Hefeng Huang. Reduced Expression and Function of Aquaporin-3 in Mouse Metaphase II Oocytes Induced by Controlled Ovarian Hyperstimulation Were Associated with Subsequent Low fertility Rate. Cell Physiol and Biochem, 2008; 21: 123-128.