叶枫

[简 历]

2005年毕业于浙江大学医学院妇科肿瘤专业，获博士学位。近年来一直从事妇科肿瘤的分子生物学发病机制的研究，在国内外核心学术期刊上发表论文三十余篇。参与妇女生殖与健康重点实验室的建设，指导研究生从事妇科恶性肿瘤的分子生物学基础研究。

研究方向：

1、妇科肿瘤

2、分子肿瘤学

承担科研项目：

1.siRNA表观遗传学上调控宫颈癌HPV16癌基因表达分子靶点。高等学校博士学科点专项科研基金，2008.1-2010.12，排名1/9

2.染色体11q22-q25区候选抑癌基因高甲基化和宫颈癌的发生机制，浙江省自然基金(Y205190)，2006.1-2008.12，排名：1/7

3.喜树碱对耐紫杉醇卵巢癌细胞的作用机制研究，浙江省中医药局(2006C089)，2006.1-2007.12，排名：1/7

4.Notch蛋白及其靶基因Hes1、Hes5在宫颈癌细胞分化中作用的研究，浙江省卫生厅青年项目(2006QN018)，2006.7-2008.12，排名：1/4

5.抑癌基因启动子CpG岛高甲基化与宫颈癌发生, 浙江省教育厅( 20050971), 2005.7- 2006.12，排名1/6

6.卵巢癌肿瘤干细胞的分离、鉴定及其在化疗耐药中的分子机制。浙江省卫生厅面上项目(2007A129)，2007.7- 2009.12，排名1/8

代表性论著：

(1)Ye F, Chen HZ, Xie X, Ye DF, Lu WG, Ding ZM. Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells. Gynecol Oncol. 2004 Jul;94(1):125-33.

(2)Ye F, Chen HZ, Xie X, Ye DF, Lu WG. Ovarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells derived from hematopoietic progenitor cells in vitro. Cancer Invest. 2005;23(5):379-85.

(3)Ye F, Chen HZ, Liang ZX, Lu WG, Cheng Q, Xie X. Establishment of Cervical Cancer Model via Inoculating SiHa Cells into Humanized Severe Combined Immunodeficient Mice. Eur J Gynaecol Oncol. 2006;27(6):566-72.

(4)Ye F, Zhang SF, Xie X, Lu WG. OPCML Gene Promoter Methylation and Gene Expression in Tumor and Stroma Cells of Invasive Cervical Carcinoma. Cancer Invest. 2008, accepted.

(5)Huang J, Ye F, Chen H, Lu W, Xie X. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis. 2007 Jun;28(6):1314-22. Epub 2007 Jan 18.

(6)Huang J, Ye F, Chen H, Lu W, Xie X. The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. Int J Gynecol Cancer. 2007 May-Jun;17(3):668-75.

(7)Li X, Ye F, Chen H, Lu W, Wan X, Xie X. Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Lett. 2007 Aug 8;253(1):144-53.

(8)Zhou JH, Ye F, Chen HZ, Zhou CY, Lu WG, Xie X. Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Life Sci. 2006 Apr 25;78(22):2643-9. Epub 2006 Jan 24.

(9)Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X. Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1293-9.

(10)Hong D, Ye F, Chen H, Lü W, Cheng Q, Hu Y, Xie X. Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China. Int J Gynecol Cancer. 2007 Apr 26;

(11)Chen H, Ye F, Zhang J, Lu W, Cheng Q, Xie X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2007;28(6):464-7.

(12)Ma Y, Ye F, Lv W, Cheng Q, Chen H, Xie X. Correlation between soluble Fas level and apoptosis of T cells in ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 2007 Sep 7; [Epub ahead of print]

(13)Lu WG, Ye F, Shen YM, Fu YF, Chen HZ, Wan XY, Xie X. EMA-CO chemotherapy for high-risk gestational trophoblastic neoplasia: a clinical analysis of 54 patients. Int J Gynecol Cancer. 2007 Aug 17; [Epub ahead of print]

(14)Chen, H; Ye, F; Zhang, J; Lu, W; Cheng, Q; Xie, X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2008; [Epub ahead of print]

[主攻学科]

实验室

[研究方向]

妇科肿瘤、分子肿瘤学